Searchable abstracts of presentations at key conferences in endocrinology

ea0090p98 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Investigation of Brain CD47 Expression and Its Relation with Cognitive Functions in Diabetic Mice Models

Kiriscioglu Nil , Asadi Amirhooman , Guven Mucahit , Ozkan Esra , Kocabay Ahmet , Deyneli Oguzhan , Yazici Dilek , Tutuncu Yildiz

Background: Diabetes Mellitus (DM) is an endocrine disorder resulting in hyperglycaemia that affects many vital organs of the body like the brain. The molecular mechanisms underlying dementia, memory loss and cognition dysfunction caused by DM are still not very clear. CD47 is a cell surface protein working in the homeostasis of the immune system. The causal relationship of CD47 has been shown in neurodegenerative diseases. CD47 also has a role in pancreatic islet cells and th...